Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts in the microenvironment and growing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have discovered recurrent mutations in genes regulating tumor cell-microenvironment interactions, which ... https://leonardou653pzg0.wikijm.com/user