Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts within the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific studies have recognized recurrent mutations in genes regulating tumor cell-microenvironment inter... https://irvingj307aip4.newsbloger.com/profile