You will find there's release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors inside the dorsal horn to lessen afferent pain transmission and generate analgesia. Consequently, drugs like clonidine that target alpha-2 receptors can affect the transmission of discomfort. Clonidine is dispersed in breast milk; https://annep603izm0.wikinstructions.com/user