Epidural clonidine used as an adjunct to area anesthetics has three distinct mechanisms of action. Initially, the stimulation of alpha-two-receptors within the dorsal horn decreases pain transmission. Next, clonidine can cause area vasoconstriction that boundaries vascular removal of local epidural anesthetics. Clonidine is distributed in breast milk; caution is https://www.proleviate.com/post/the-new-pain-killer-conolidine